Figure 8: Model of GPVI-Fc and Cross-Linked GPVI-Fc Binding to Plaque Collagen

Cross-linking of dimeric glycoprotein VI–fragment crystallizable (GPVI-Fc) fusion protein (GPVI, brown; Fc, blue) by anti–Fc Fab2 creates oligomeric (n = 2 to 4) GPVI-Fc molecules, which bind to their corresponding motifs on collagen fibers more densely (bottom) than GPVI-Fc (top).