Figure 8: CD137/NFATc1 Axis Activated NLRP3 Inflammasome in Vascular Smooth Muscle Cells

(A) Western blot and quantitative results of NLRP3, pro-IL-1β, and mature IL-1β in vascular smooth muscle cells treated with TNF-α or recombinant CD137L. Values are mean ± SEM of 3 samples in each group; *p < 0.05. (B) Western blot and quantitative results of NFATc1, NLRP3, pro-IL-1β, and mature IL-1β in vascular smooth muscle cells with knocked-down NFATc1. Values are mean ± SEM of 3 samples in each group; *p < 0.05. (C) Concentration of IL-1β in supernatants of vascular smooth muscle cells with different treatments. Values are mean ± SEM of 3 samples in each group; *p < 0.05. Abbreviations as in Figures 2, 5, and 7.

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