Figure 8: Angiotensin II Type 1 Receptor and Mineralocorticoid Receptor Expression in Right Ventricle Tissue

(A) Western blot analyses revealed significant reduction of AT1-receptor expression in the RV homogenates after RD in the MCT model in comparison to the sham-group. (B) However, no significant reduction was found in AT1-receptor expression in the SuHx model. (C and D) After RD, Western blot analyses revealed a significant reduction in the expression of MR-receptor in the SuHx-model. Protein expression was normalized by GAPDH, as a loading control. On right side: Control: n = 5, MCT-sham: n = 7, MCT-RD: n = 9; on the left side: Control: n = 6, SuHx-sham: n = 8 and SuHx-RD: n = 8. Data are presented as mean ± SEM. One-way ANOVA followed by Bonferroni correction. GAPDH = glyceraldehyde 3-phosphate dehydrogenase; other abbreviations as in Figures 1 and 6.