Figure 7: Proposed Model of TRPC-6-Dependent Endocardial/Myocardial Feedback Loop

Paracrine effects of the AE on myocardial Ca2+ transient characteristics differ under baseline conditions and with varying duration of stretch, and are dependent on reciprocal changes in endocardial TRPC-6 activity and endothelin-1 secretion. Abbreviations as in Figures 1, 2, 3 and 6.