Figure 7: Presence of LysoPA Species in Valve Leaflets and Relationship to Valve Gradients

Prevalence of (A) individual lysophosphatidic acid (LysoPA) species and (B) total LysoPA mass and (C) mean and peak valvular gradients in 4 different stenotic aortic valves. Reverse-phase separation followed by tandem mass spectrometry detection of (A) LysoPA species 16:0, 18:2, 18:1, 18:0, 20:4 and 22:6 in 4 aortic valves and (B) the total LysoPA amounts per milligram of valve tissue extracted. (C) Represents the mean and peak valvular gradients for each of the study valves.