Figure 7: GMCT Reduces AF Inducibility and Promotes AF Termination

(A) Kaplan-Meier plot for freedom from 35d-PeAF in saline-treated (N = 10) and GMCT-treated groups (N = 10). p = 0.3254. (B) Number of AF terminations after 7d-PeAF for saline-treated (N/n = 3/29) and GMCT-treated groups (N/n = 7/82). (C) Left: AF inducibility index for saline-treated (N = 10) and GMCT-treated groups (N = 10) throughout AF progression. #p < 0.0001 versus saline-treated animals. (Right) AF inducibility index after 7d-PeAF in GMCT-treated (N/n = 7/77) and saline-treated (N/n = 3/32) animals. (D) (Left) AF burden in GMCT-treated (N = 10) and saline-treated (N = 10) animals. (Right) Overall AF burden in GMCT-treated (N/n = 10/199) and saline-treated (N/n = 10/187) animals. N = number of animals; n = number of AF episodes. Statistics: (A) Gehan-Breslow-Wilcoxon test, (C, D left) Mann-Whitney U test at each individual time point, (B, C, D right) Mann-Whitney U test. *p < 0.05, **p < 0.01. Abbreviations as in Figure 4.