Figure 6: miR-24 Overexpression Ameliorates Diabetic Ischemia/Reperfusion Injury

We observed an increase in mortality post-myocardial infarction or ischemia/reperfusion (I/R) in type 2 diabetic mice. We also found a reduction of plasma and heart miR-24 levels in diabetic mice. Systemic enrichment of miR-24 in db/db mice or cardiomyocyte-specific overexpression of miR-24 in wild-type (WT) mice significantly reduced myocardial infarct size and alleviated cardiac injury. The possible mechanism underlying miR-24–based therapeutics in diabetic I/R may involve O-GlcNac transferase (OGT)–mediated heart protein O-GlcNAcylation, autophagy-related gene 4a (ATG4A)–mediated autophagy, and Bcl-2-like protein 11 (BIM)–mediated apoptosis.

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