Figure 6: Identification of New AnkG-Associated Cellular Pathways

(A) Representative heat map of transcript analysis of the left ventricle of control and AnkG cKO mice. Of >25,000 transcripts analyzed, fewer than 500 displayed a significant change in expression (n = 3/genotype; p < 0.05). (B and C) Analysis of differentially expressed transcripts between control and AnkG cKO mice. Notably, 21.5% of these transcripts represent cytoskeletal, cytoskeletal-binding, and/or cell adhesion molecules. (D) Selective analysis of differentially expressed cytoskeletal and cell adhesion transcripts between control and AnkG cKO left ventricle. (E) Selective analysis of differentially expressed ion channel subunit transcripts between control and AnkG cKO left ventricle (p < 0.05). Abbreviations as in Figures 2 and 3.

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