Figure 6: Assessment of Electrical Conduction in the SAN in Wild-Type Mice Co-Treated With Ang II and the NPR-C Agonist cANF

(A) Maps show wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). (B) (C) Summary data for cycle length (B) and SAN CV (C) in wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). (B) *p = 0.013 versus saline; +p < 0.001 versus Ang II. (C) *p < 0.001 versus saline; +p < 0.001 versus Ang II. Data were analyzed by 1-way analysis of variance with Tukey post hoc test; n = 16 hearts for saline, 24 hearts for Ang II, 8 hearts for Ang II + cANF (0.07 mg/kg/day), and 8 hearts for Ang II plus cANF (0.14 mg/kg/day). (D) Representative spontaneous SAN optical APs in wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). Dashed lines run through the maximum diastolic potential. Abbreviations as in Figures 1, 2, and 5.