Figure 5: Therapeutic Benefit of MPO Inhibitor Treatment Is Maximized by Initiating Treatment Close to the Event

Mice were subjected to coronary artery occlusion. MPO inhibitor treatment (50 mg/kg, twice daily) was initiated at 1 h (MI early Txi, n = 15) or 24 h (MI delayed Txi, n = 13) post-surgery. Vehicle treatment started at 1 h as control (MI vehicle, n = 11). Cardiac function was evaluated by echocardiography. (A) Representative left ventricular M-mode images. (B to E) Bar graphs represent ejection fraction (EF), fractional shortening (FS), stroke volume, and left ventricular end-systolic volume (ESV). Data plotted as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Txi = treatment initiation; other abbreviations as in Figures 1, 2, and 3.