Figure 5: Renal Denervation Reduced Right Ventricular Hypertrophy and Fibrosis

Representative examples of RV cross-sectional area (hematoxylin and eosin stain) and fibrosis (Picrosirius red stain) (scale bar, 20 μm). (A) Examples from an MCT-treated animal. (B) Examples from a SuHx model. RD reduced significantly the RV cross-sectional area (C: MCT; D: SuHx). RD reduced the RV fibrosis, especially in the SuHx-model (E: MCT; F: SuHx). Right side: Control: n = 5, MCT-sham: n = 9, and MCT-RD: n = 9. Left side: Control: n = 6, SuHx-sham: n = 10, and SuHx-RD: n = 10. Data are presented as mean ± SEM. Multilevel analysis has been performed to correct for non-independence of successive measurements per animal. Abbreviations as in Figure 1.