Figure 5: Oxidative Function of Mitochondria in the Nonfailing Donor Heart and in the Advanced Failing Heart at Pre- and Post-LVAD Unloading Time Points

Complex I, complex I + II, and complex IV respiration of isolated permeabilized myofibers from failing hearts was significantly lower compared with the nonfailing heart. Mitochondrial oxidative capacity remained significantly reduced after left ventricular assist device (LVAD) unloading. *p < 0.05; **p < 0.01; ***p < 0.001.