Figure 5: Monoclonal Antibodies to IL-17F Have No Effect on Renal and Aortic Inflammation

Quantification of total leukocytes (CD45+ cells), total T lymphocytes (CD3+ cells), and T-cell subsets (CD4+ and CD8+) per kidney (A) or thoracic aorta (B) in mice infused with Ang II for 4 weeks and treated with either IL-17F neutralizing antibody or corresponding rat IgG1 isotype control twice weekly during the last 2 weeks of Ang II infusion. Data were analyzed using Student t test and expressed as mean ± SEM (n = 12 per group). Abbreviations as in Figures 1, 2, and 3.