Figure 5: Lack of Fstl1 Increases Cardiac Myocyte Hypertrophy in HFpEF Mice

(A) Cardiac myocyte hypertrophy in the left ventricle (LV) (left, representative hematoxylin and eosin images, scale bar: 10 μm) and quantitative measure of cardiac myocyte cross-sectional area (right). (B) Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNA expression in WT and cFslt1-KO mice with aldosterone (HFpEF) or saline (Sham) infusion. n = 6 to 12 mice/group. Data are mean ± SEM. Statistical analysis by analysis of variance followed by Newman-Keuls multiple comparison tests. Abbreviations as in Figures 1 and 4.