Figure 5: Heart Collagen 1 and III, ANP mRNA Levels

Hearts of DOCA salt rats showed evidence of atrial natriuretic peptide (ANP) activation, together with increased collagen I (Col I) and III mRNA. Empa had no effect on either ANP, or Col I or III mRNA. n = 8 for control (Cont) UNX; n = 7 for UNX empa; n = 14 for control DOCA; n = 13 for empa DOCA. *p < 0.05 compared to UNX animals treated with UNX + control. RPL13a = ribosomal protein L13A housekeeping gene; other abbreviations as in Figure 1.