Figure 5: Glucose Disposal

Normal mice received IV saline (n = 12), AAV8.UCn2 (1.9 × 1013 gc/kg, n = 10), or AAV8.UCn3 (1.9 × 1013 gc/kg, n = 12). Eight to 10 weeks later, fasting (12-h) glucose was determined, and glucose tolerance testing was performed. (A) A group difference in fasting blood glucose was detected (ANOVA, p = 0.0002). Mice that had received UCn2 gene transfer showed reduced fasting glucose (p < 0.001 vs. control; p < 0.001 vs. UCn3). Individual mouse data are shown, and mean ± SE are indicated. (B) Glucose tolerance testing showed a difference in glucose clearance (ANOVA, p = 0.015). The area under the glucose time curve was reduced in animals that had received UCn2 gene transfer (p = 0.02 vs. control; p < 0.02 vs. UCn3). Between-group comparisons are from Sidak multiple comparison test with correction. Abbreviations as in Figure 1.