Figure 5: Effect of ApoA-I Infusions on Early-Stage Descending Thoracic Aorta Lesions in Diseased/Aged Mice

Descending thoracic aorta plaque area was quantified histologically (A) and plaque burden was assessed using micro-CT (B). Paraffin-embedded sections were quantified immunohistochemically for F4-80+ macrophage content (C) and α-actin+ SMC content (D). Upper panels display images of representative sections (scale bar indicates 100 μm). Data are mean ± SD. Baseline n = 5, saline n = 11 to 18, apoA-I n = 13 to 15 mice/treatment. *p ≤ 0.05. Micro-CT = micro-computed tomography; other abbreviations as in Figure 1.

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