Figure 5: Coronary Relaxation in Gotokakisaki Rats

(Upper panel) Coronary relaxation induced by acetylcholine 90 days after sham surgery in untreated Goto-Kakisaki (open circles; n = 5) or 90 days after 20-min transient ischemia in placebo-treated I/R Goto-Kakisaki (filled circles; n = 8), early long-term (down-triangles; n = 6) or delayed long-term gevokizumab-treated I/R Goto-Kakisaki (up-triangles; n = 6). *p < 0.05 versus untreated sham. †p < 0.05 versus placebo-treated I/R. (Middle and lower panels) Coronary relaxation induced by acetylcholine 90 days after sham-surgery in IgG-treated Goto-Kakisaki or 90 days after 20-min transient ischemia in placebo-treated I/R Goto-Kakisaki, early long-term or delayed long-term gevokizumab-treated I/R Goto-Kakisaki before (open circles) and after incubation with apocyin or SOD (filled circles). *p < 0.05 versus before incubation.