Figure 5: Cardiomyocyte-Targeted Nox4 Overexpression Improves Post-MI Survival and Protects Against Adverse Remodeling

(A) Kaplan-Meier survival curves after MI in TG and WT (mouse numbers at 0, 7, 14, 21, and 28 days after MI: TG, 27, 26, 26, 26, and 26; WT, 37, 28, 28, 27, and 27). (B) Infarct size 24 h and 4 weeks after MI. n = 6 per group. (C and D) Echocardiographically quantified left ventricular EDV and EF after MI. n ≥ 15 per group. (E and F) Invasive cardiac contractile function assessed by maximum derivative of left ventricular pressure (dP/dtmax) and minimum derivative of left ventricular pressure (dP/dtmin). n = 8 per group. (G) Postmortem HW/BW. (H) Interstitial fibrosis in remote myocardium of TG and WT hearts after MI. n = 6 per group. #Significant interaction according to 2-way analysis of variance. LV = left ventricle; other abbreviations as in Figure 1.

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