Figure 5: Assessment of Heart Rate and SAN Function in Wild-Type Mice Co-Treated With Ang II and the NPR-C Agonist cANF

(A) Representative ECG recordings and SNRT measurements during intracardiac programmed stimulation in wild-type mice treated with saline, Ang II. or Ang II plus cANF (0.07 or 0.14 mg/kg/day). (B) (C) Summary of heart rate (B) and cSNRT (C) in wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). (B) *p < 0.001 versus saline; +p = 0.009 versus Ang II; ˆp = 0.006 versus Ang II plus cANF (0.07). (C) *p < 0.001 versus saline; +p < 0.001 versus Ang II; p = 0.006 versus Ang II plus cANF (0.07). Data were analyzed by 1-way analysis of variance with Tukey post hoc test; n = 28 mice for saline, 29 mice for Ang II, 20 mice for Ang II plus cANF (0.07 mg/kg/day) and 22 mice for Ang II plus cANF (0.14 mg/kg/day). cANF = NPR-C agonist; other abbreviations as in Figure 1.