Figure 5: Antifibrotic Effects Underlie the Benefits of CDCs in HFpEF

(A) Representative heart sections stained with picrosirius red in control, placebo-treated, and cardiosphere-derived cell (CDC)–treated rats. Left ventricular (LV) fibrosis (B) and right ventricular (RV) fibrosis (C) quantified from such images is higher in placebo- than in CDC-treated and control rats. (D) Collagen 1A1 and collagen 3 content is higher in placebo- than in CDC-treated and control rats. (E) Immunostaining for α–smooth muscle actin (SMA) in control and placebo- and CDC-treated rats. Myofibroblast infiltration into the heart is higher in placebo- than in CDC-treated and control rats. n = 6 to 8 in each group. †p < 0.05 versus control and CDC-treated rats by analysis of variance.