Figure 5: AnkG cKO TAC-Induced Mortality Not Associated With Tachyarrhythmias

Representative ECGs from ambulatory control mice at (A) baseline and (B) 2 weeks post-TAC reveal an increase in resting heart rate in response to TAC. (C) ECGs from ambulatory AnkG cKO mice demonstrate decreased resting heart rate at baseline. (D) In response to TAC, AnkG cKO mice display decreased resting heart rate relative to wild-type controls. Scale bar = 100 ms. (E) Quantification of average resting heart rates in all experimental groups (n for each group listed in bar graph; p < 0.05). AnkG cKO mice display increased (F) PR interval and (G) QRS interval at baseline and after TAC relative to controls (n for each group listed in bar graph; p < 0.05). (H) AnkG cKO mice show an increased rate of spontaneous death. (I) Telemetric monitoring demonstrates that AnkG cKO animals develop severe bradycardia eventually leading to death. Scale bar = 250 ms. BPM = beats/min; other abbreviations as in Figures 2 and 3.

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