Figure 4: Stained Sections

(A to D) Representative hematoxylin and eosin and (E to H) picrosirius red stained sections. Hearts of UNX + DOCA salt rats showed evidence of (I) myocyte hypertrophy, together with both (J and K) perivascular and interstitial fibrosis. Empa reduced cardiomyocyte size in UNX + DOCA animals but had no effect on either interstitial or perivascular fibrosis. n = 7 to 8 in UNX control and UNX empa groups; n = 16 and 15 in DOCA control and empa groups, respectively. *p < 0.05 treated with UNX + control. †p < 0.05 treated with UNX + DOCA + control. CSA = cross-sectional area; other abbreviations as in Figure 1.