Figure 4: Renal Denervation Reduced the Pulmonary Vascular Remodeling

Representative examples of pulmonary arterioles (Elastica van Gieson) (scale bar, 20 μm). (A) Examples from the MCT model. (B) Examples from the SuHx model. RD reduced significantly the wall thickness of the pulmonary arterioles, as observed by a reduction in both the media (C: MCT; D: SuHx), and intima layers (E: SuHx). In addition, RD increased significantly the percentage of open vessels and reduced the number of full obliterated vessels in both PH-models (F: MCT; G: SuHx). A: Control: n = 5, MCT-sham: n = 9, and MCT-RD: n = 9; B: Control: n = 6, SuHx-sham: n = 10, and SuHx-RD: n = 10. Data are presented as mean ± SEM. Multilevel analysis to correct for non-independence of successive measurements per animal. FO = fully obliterated vessels; PO = partially obliterated vessels; other abbreviations as in Figure 1.