Figure 4: Nox4 Modulates Cardiac Macrophage Polarization After Permanent LAD Ligation

Cardiomyocyte Nox4 drives polarization in a region-specific manner after permanent left anterior descending coronary artery (LAD) ligation. (A and B) Representative pseudocolor plots for macrophages based on Ly6c or MRC1 expression. Nox4 drives an inversion of the Ly6c expression pattern in the remote myocardium of TG. (C and D) Ly6c- and MRC1+ macrophage proportions in the infarct and remote area. n = 5 to 6 per group. Abbreviations as in Figure 1.

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