Figure 4: Mean AUC for Absolute Change in LVEF Over 90 Days

(A) The mean AUC for change in LVEF over 90 days in all patients is displayed for the placebo (grey), low-dose (green), and high-dose (blue) groups (with the lighter portion in the high-dose group including cohort 7). The high-dose group had a significantly greater increase in LVEF when compared with the low-dose or placebo groups. This was significant whether the highest dose (1.5 mg/kg) cohort was included (lighter blue bar) or not (darker blue bar) (p < 0.01). (B) The mean AUC for change in LVEF over 90 days in all patients is displayed for each individual dose cohorts and plotted on a logarithmic scale. The individual dose cohorts that were grouped into the placebo, low and high dose are color coded as in A. R2 = 0.6735. The Jonckheere-Terpstra test showed a significant relationship between dose and change in LVEF AUC 0-90 (p = 0.0012). AUC = area under the curve; LVEF = left ventricular ejection fraction.

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