Figure 4: Mean AUC for Absolute Change in LVEF Over 90 Days
2019-06-11T07:03:04Z (GMT) by
(A) The mean AUC for change in LVEF over 90 days in all patients is displayed for the placebo (grey), low-dose (green), and high-dose (blue) groups (with the lighter portion in the high-dose group including cohort 7). The high-dose group had a significantly greater increase in LVEF when compared with the low-dose or placebo groups. This was significant whether the highest dose (1.5 mg/kg) cohort was included (lighter blue bar) or not (darker blue bar) (p < 0.01). (B) The mean AUC for change in LVEF over 90 days in all patients is displayed for each individual dose cohorts and plotted on a logarithmic scale. The individual dose cohorts that were grouped into the placebo, low and high dose are color coded as in A. R2 = 0.6735. The Jonckheere-Terpstra test showed a significant relationship between dose and change in LVEF AUC 0-90 (p = 0.0012). AUC = area under the curve; LVEF = left ventricular ejection fraction.