Figure 4: LV

(A) LV 99mTc-RP805 uptake between controls (n = 5) and DOX-treated rats (n = 5) at 4 weeks, and controls (n = 5) and DOX-treated rats (n = 4) 8 weeks following chemotherapy initiation. Correlation between (B) LV ejection fraction and LV 99mTc-RP805 uptake, and (C) LV end-systolic volume and LV 99mTc-RP805 uptake in DOX-treated rats at 8 weeks (n = 4) and matched controls (n = 5). **p = 0.01 between-group difference. ‡p < 0.05 within-group difference compared with 4-week rats. Values are expressed as median with interquartile range. Inj. = injected; MMP = matrix metalloproteinase; other abbreviations as in Figures 1, 2, and 3.