Figure 4: Impact of GLC and GLC Receptor Antagonist on Cardiac Function and Chamber Dilation in Post-Myocardial Heart

(A) Fractional shortening and (B) left ventricular end-systolic dimension (LVESD) in MI hearts treated with PBS (Control; n = 10, blue), GLC (n = 6, purple), and GLC receptor antagonist (REMD; n = 11; red) at different time points recorded by echocardiogram. #p < 0.05 REMD versus Control; REMD versus GLC. (C) Left ventricular developed pressure (LVDP). (D) Left ventricular systolic pressure (LVSP). (E) Maximum pressure derivative (+dP/dtmax) and (F) Minimum pressure derivative (–dP/dtmin) as measured by conductance catheter. Abbreviations as in Figure 1.