Figure 4: Coronary Relaxation in Wistar Rats

(Upper panel) Coronary relaxation induced by acetylcholine 90 days after sham surgery in untreated Wistar (open circles; n = 5) or 90 days after 45-min transient ischemia in placebo-treated I/R Wistar (filled circles; n = 6), early long-term (down-triangles; n = 15) or delayed long-term gevokizumab-treated I/R Wistar (up-triangles; n = 5). *p < 0.05 versus untreated sham. †p < 0.05 versus untreated I/R. (Middle and lower panel) Coronary relaxation induced by acetylcholine 90 days after sham surgery in untreated Wistar or 90 days after 45-min transient ischemia in untreated I/R Wistar, early long-term or delayed long-term gevokizumab-treated I/R Wistar before (open circles) and after incubation with apocyin or SOD (filled circles). *p < 0.05 versus before incubation.