Figure 4: BLVRB Localizes to CD68+ Cells in Plaques

In plaque transcriptomic (A) and proteomic (B) datasets, BLVRB showed strong significant correlations to markers of macrophages (CD163, CD36). By double immunohistochemistry, BLVRB (red signal) localized primarily to CD68+ cells in the necrotic core of plaques (green signal, enlarged insets). No signal was observed in adventitia of normal arteries (C). By single immunohistochemistry, BLVRB was also detected in necrotic core regions positive for CD163 (D). neg = negative; other abbreviations as in Figures 1 and 2.