Figure 4: Adult Cardiomyocyte-Specific Ablation of

Excised hearts, MCM Cre– and MCM Cre+, were subjected to 30 min of baseline measurement, followed by 45 min of no-flow ischemia, which was followed by 60 min of reperfusion. (A) Baseline left ventricular developed pressure (LVDP) was reduced in MCM Cre+ hearts, consistent with echocardiography data. *p = 0.002. (B) Following ischemia, MCM Cre+ hearts show improved recovery of LVDP compared with MCM Cre– hearts. *p < 0.02. (C) Baseline left ventricular maximal contractility (maximal rate of pressure development [+dP/dT]) was reduced in MCM Cre+ hearts. *p = 0.04. (D) Recovery of left ventricular maximal contractility +dP/dT was more efficient in MCM Cre+ hearts than in MCM Cre– hearts (*p = 0.04). (E) Baseline left ventricular maximal relaxation (maximal rate of pressure decline during relaxation [–dP/dT]) was reduced in Cre+ hearts. *p = 0.07. (F) Recovery of left ventricular maximal relaxation –dP/dT was more efficient in MCM Cre+ hearts than in MCM Cre– hearts (* p = 0.01). (A to F) n = 7, 8 hearts. Abbreviations as in Figures 1 and 2.

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