Figure 3: RBCs From db/db Mice Impair Cardiac Post-Ischemic Functional Recovery

(A) Hearts from WT mice were given Krebs-Henseleit (KH) buffer (WT heart + KH, n = 5) or RBCs from WT mice (WT heart + WT RBCs, n = 5), and hearts from db/db mice were given KH buffer (db/db heart + KH, n = 4) or RBCs from db/db mice (db/db heart + db/db RBCs, n = 9). (B) Hearts from WT mice were given RBCs from either WT (n = 5) or db/db (n = 5) mice. (C) Hearts from db/db mice were given RBCs from either WT (n = 5) or db/db (n = 6) mice. (D) Infarct size in WT hearts given RBCs from WT or db/db mice. Post-ischemic left ventricular developed pressure (LVDP) is expressed as percentage recovery from the pre-ischemic level. Significant differences between groups in A to C were analyzed using 2-way analysis of variance including all time points, whereas Student's t-test was performed in D; *p < 0.05 and ***p < 0.001. Abbreviations as in Figure 1.