Systolic blood pressure was measured at baseline and weekly during 28 days of Ang II infusion. Arrows indicate timing of antibody administration. Data are expressed as mean ± SEM and were analyzed at day 28 using 1-way analysis of variance followed by Holm-Sidak post hoc test (n = 7 to 20 per group). ***p < 0.001 vs. mouse IgG1. Ab = antibody; other abbreviations as in Figures 1 and 2.