Figure 3: Mean Absolute Change in LVEF After Dosing
2019-06-11T07:03:03Z (GMT) by
The mean absolute change in LVEF from baseline for the patients in the placebo, pooled low-dose, and high-dose groups are displayed over 90 days. The dashed line represents the high-dose group with cohort 7 (highest dose 1.5 mg/kg, with DLT) data included. Since this dose will no longer be developed clinically, the solid blue line represents the data without this cohort. There was a significant increase in LVEF at 30 days between the high groups compared with placebo (p < 0.01). At 90 days, only the highest dose group showed a significant increase compared with the placebo group (p < 0.01). Abbreviations as in Figures 1 and 2.