Figure 3: Lesion Quantification

(A) Average cross-sectional intima area in left anterior descending (LAD) coronary artery. (B, C) Representative examples (green dots in A) of lesions in the LAD of an APOE+/+ (B) and an APOE−/− (C) Yucatan minipig. Arrows indicate examples of foam cells. Scale bar = 100 μm. Both are examples of xanthomas with intima containing foam cells. (D, E) Representative examples (red dots in F and G) of en face stained aortic lesions from an APOE+/+ (D) and an APOE−/− (E) Yucatan minipig. In both, abdominal aorta is depicted left and thoracic aorta depicted right. Red areas (stained with Sudan IV) represent lipid-rich areas of the aortic intima. (F) Surface covered with red-stained area in the thoracic aorta (mainly non-raised lesions). (G) Surface covered with red-stained area in the abdominal aorta (mainly raised lesions). **p = 0.0020. (H) Surface covered with red-stained area in the iliofemoral arteries. **p = 0.0059. In A, F to H: APOE+/+ n = 13 and APOE−/− n = 11. Bars indicate median.