Figure 3: Intravenous Sodium Nitrite Induced Endothelial Post-Conditioning in

(A) IR produced significant endothelial dysfunction in ALDH2*1/*2 individuals (p < 0.0001, n = 9). (B) IR produced significant endothelial dysfunction in ALDH2*1/*1 individuals (p = 0.0001, n = 9). (C) Intravenous sodium nitrite (1 μg/kg/min) administered during the final 10 min of ischemia prevented endothelial dysfunction in ALDH2*1/*2 individuals (p = 0.63, n = 8). (D) Intravenous sodium nitrite (1 μg/kg/min) administered during the final 10 min of ischemia did not prevent endothelial dysfunction in ALDH2*1/*1 individuals (p = 0.006, n = 10); **p < 0.01, ***p ≤ 0.0001. Solid circles = pre-ischemia FBF-R; open circles = post-ischemia FBF-R. IR = ischemia–reperfusion; other abbreviations as in Figures 1 and 2.