Figure 3: Individual Total Activity Measurements of CI, CIV, and Citrate Synthase in Subsarcolemmal Mitochondria

(A to C) Enzyme activities of CI, CIV, and citrate synthase are lower, trending lower, and unchanged, respectively, in untreated HF versus NF controls. (D to F) Activities of CI, CIV, and citrate synthase are unaltered with elamipretide treatment in NF hearts. (G to I) Individual activities of CI and CIV increase with elamipretide treatment in HF, with citrate synthase unchanged. Untreated hearts in (C to G) are shown with closed circles and treated hearts with open circles. NF, n = 11; HF, n = 12. Abbreviations as in Figure 1.