Figure 3: Immunohistochemical Results for ISO Alone (Summative Data)

Effects of isoproterenol (ISO) on regional accumulation of 3-nitrotyrosine (3-NT), poly(ADP-ribose) (PAR), and thioredoxin-interacting protein (TXNIP) in left ventricular myocardium. (A) 3-NT mean values at apex and base. Two-way analysis of variance (ANOVA): ISO, p = 0.002; apex/base, p = 0.03; and interaction, p = 0.23. (B) PAR mean values at apex and base. Two-way ANOVA: ISO, p < 0.0001; apex/base, p = 0.01; and interaction, p = 0.93. (C) TXNIP mean values at apex and base. Two-way ANOVA: ISO, p < 0.0001; apex/base, p = 0.002; and interaction, p = 0.57. Two slides were analyzed per rat (apex and base); values are mean ± SEM. *p < 0.05.