Figure 3: Example Box-and-Whisker Plots Illustrate Changes in Biomolecule Concentrations Across Coronary Atherosclerotic Plaques

Paired summary figures show concentration of biomolecules at proximal (prox), mid, and distal sampling ports of LBS. The upper row shows samples obtained before and the bottom row balloon pre-dilation of plaque. False discovery rate p values are noted at top right of each graph; p(FDR) <0.05 indicates significant changes in biomolecular gradients. Sampled biomolecules labeled by Human Genome Organization designation show significant gradients in oxidized low-density lipoprotein receptor-1/LOX-1 (OLR1) before but not after balloon dilation; in matrix metalloproteinase (MMP)-12 after but not before dilation; in interleukin (IL)-8; and in platelet-derived growth factor B (PDGFB) before and after balloon dilation; and no gradient in growth hormone (GH), acting as a negative control. Box and whisker plots show median, interquartile range, and range, with outliers designated as points. Abbreviations as in Figures 1 and 2.