Figure 3: Diastolic Function, Cardiac Fibrosis, and Macrophage Infiltration Showed No Differences in Mice With Heart Failure Treated With Empagliflozin

Hearts from vehicle- and Empa-treated mice with HF displayed no significant changes in indices of diastolic function such as the left ventricular filling ratio E/E′ (A) and mitral E/A ratio (B) (n = 6 to 10). Representative images of left ventricular heart sections taken mid-papillary and stained with Masson’s trichrome at ×20 magnification (C) and hematoxylin-eosin stain ([D] n = 5 to 7). Scale bars = 100 μm. Results are mean ± SEM. Comparisons between groups were performed using Mann-Whitney U test. Abbreviations as in Figure 1.