Figure 3: Adenosine Receptor Inhibition Abrogates rIPC Signal Generation

(Top) Protocol 1 results. Left shows the results from control studies showing that caffeine does not itself alter the response to rIPC/IR injury. Middle shows no significant change between FMD 1 and FMD 2. FMD 3 was not reduced, confirming rIPC was effective in the placebo group. Right shows no significant change between FMD 1 and FMD 2, confirming that caffeine itself did not affect FMD. FMD 3 was significantly reduced confirming rIPC was inhibited in the caffeine group. (Middle) Protocol 2: study 1 results. Left shows the significant reduction in FMD responses after rIPC/IR with infusion of caffeine in the trigger arm. This confirms inhibition of the protective effect of rIPC. Right shows the effect of dialysate produced on myocardial infarction (MI) showing that there is no reduction in MI, suggesting that the observed inhibition of rIPC is in part through reduction of release of a circulating factor(s). (Bottom) Protocol 2: study 2 results. Left shows no significant reduction in response to acetylcholine after rIPC and IR with infusion of caffeine in the target arm. This confirms a protective effect of rIPC. Right shows the effect of dialysate produced on MI, showing that there is a significant reduction in MI, suggesting preserved release of circulating factor(s). Abbreviations as in Figure 1.

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