Figure 2: Transthoracic Echocardiography–Derived Systolic Function and Ventricular Dimensions

(A) Ejection fraction, (B) global longitudinal strain, (C) global radial strain, (D) left ventricular (LV) end-diastolic volume, (E) end-systolic volume, and (F) relative wall thickness at baseline (CTL, n = 10; DOX, n = 10), and 4 weeks (CTL, n = 10; DOX, n = 10), 6 weeks (CTL, n = 5; DOX, n = 5), and 8 weeks (CTL, n = 5; DOX, n = 4) following the initiation of chemotherapy in DOX-treated rats and time-matched controls. *p < 0.01 between-group difference. Box plots display the median (horizontal bar), first quartile, third quartile, and minimum and maximum values (whiskers). LVPwd = left ventricular posterior wall thickness at end-diastole; LVID = left ventricular internal diameter; other abbreviations as in Figure 1.