Figure 2: Time Course and Dose Effects of BMS-986231

(A) Time course effects of BMS-986231 (50 μg/kg/min) in animals with normal cardiac function, and (B) dose effects of BMS-986231 (25, 50, and 75 μg/kg/min) after a 3-h infusion in animals with pacing-induced cardiomyopathy. All values shown are mean ± SEM. *p < 0.05 versus baseline; †p < 0.05 (3 h + HEX vs. 3 h); ‡p < 0.05 (vs. 25 μg/kg/min). EDPVR = end-diastolic pressure-volume relationship; ESPVR = end-systolic pressure-volume relationship; HEX = Hextend (plasma volume-expanding solution); LVEF = left ventricular ejection fraction; MAP = mean arterial pressure; PRSW = preload-recruitable stroke work; PVA = pressure-volume area; Tau = left-ventricular relaxation time-constant; other abbreviations as in Figure 1.

Categories

License

Elsevier user license