Figure 2: Three Mechanisms by Which Epigenetic Regulators Can Control Cardiac Fibroblast Proliferation and Myofibroblast Differentiation

2019-06-12T08:29:20Z (GMT) by Marina B. Felisbino Timothy A. McKinsey
(A) HDACs repress expression of genes encoding the cyclin-dependent kinase inhibitors, p15 and p57, which leads to enhanced retinoblastoma (Rb) protein phosphorylation and stimulation of downstream target genes that promote cardiac fibroblast proliferation. (B) Binding of BRD4 to acetyl-histone H3K27 helps create super-enhancers (SEs), which drive expression of target genes that promote extracellular matrix (ECM) production and myofibroblast differentiation. (C) DNA methyltransferase (DNMT)-mediated methylation of DNA leads to suppression of antiproliferative genes and genes that normally repress myofibroblast differentiation.

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