Figure 2: Possible Mechanisms Implicated in Radiation-Induced Vascular Injury

CAD = coronary artery disease; CNS = central nervous system; CVA = cerebrovascular accident; CXCL = chemokine ligand; IGFBP-5 = insulin-like growth factor binding protein; NEMO = nuclear factor kappa B essential modulator; PAD = peripheral artery disease; PAI = plasminogen activator inhibitor; SMA = smooth muscle actin; SPRY = sprout homolog; TLR = Toll-like receptor; vWF = von Willebrand factor; XIAP = X-linked inhibitor of apoptosis.

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