Figure 2: Modeling Variations in Cardiac Function Following Administration of Sunitinib in Rat CMT

(A) Dose-dependent decreases in spontaneous beating rates following 24 h of treatment with 0.1% dimethyl sulfoxide (vehicle n = 10 tissues), 1 μmol/l sunitinib (n = 11 tissues), or 10 μmol/l sunitinib (n = 11 tissues). ****p < 0.0001 versus vehicle; *p < 0.05 1 μmol/l sunitinib versus 10 μMmol/l sunitinib. (B) Dose-dependent decreases in static (diastolic) tension generated by CMT treated for 24 h with 0.1% dimethyl sulfoxide (n = 12 tissues), 1 μmol/l sunitinib (n = 20 tissues), or 10 μmol/l (n = 10 tissues) sunitinib. **p < 0.01 vehicle versus 1 μmol/l sunitinib, 1 μmol/l sunitinib versus 10 μmol/l sunitinib; ****p < 0.0001 vehicle versus 10 μmol/l sunitinib. Decrease in active (systolic) tension with 10 μmol/l sunitinib treatment. ****p < 0.0001 vehicle (n = 4 tissues) or 1 μmol/l sunitinib (n = 5 tissues) versus 10 μmol/l sunitinib (n = 9 tissues). We did not observe any changes in excitation threshold (C) or maximum capture rate (D) following 24 h treatment with 0.1% dimethyl sulfoxide or 10 μmol/l sunitinib. (A, C) Data are box-and-whisker plots; median-first quartile are plotted in red, third quartile-median are plotted in green, and error bars extend from median to minimum/maximum. Abbreviation as in Figure 1.