Figure 2: LV Structure, Function, and Circulating BNP Levels at 18 Weeks Post TAC

(A) (B) LVEDD and LVESD (mm) throughout the experimental protocol. (C) Percent of LVEF. (D) Left ventricular end-diastolic pressure (mm Hg) at 18 weeks following TAC. (E) LV relaxation constant Tau (ms) at 18 weeks post TAC. (F) Circulating BNP levels (ng/ml) in mice from Sham, HF + Control, HF + 3-week-delayed JK-1 treatment, and HF + 10-week-delayed JK-1 treatment. *p < 0.05 between Sham vs. HF + Control; **p < 0.01 between Sham vs. HF + Control; ****p < 0.0001 between Sham vs. HF + Control; #p < 0.05 between HF + JK-1 3 weeks post TAC vs. HF + Control; ###p < 0.001 between HF + JK-1 3 weeks post TAC vs. HF + Control; ####p < 0.0001 between HF + JK-1 3 weeks post TAC vs. HF + Control; $p < 0.05 between HF + JK-1 10 weeks post TAC; $$$p < 0.001 between HF + JK-1 10 weeks post TAC; $$$$p < 0.0001 between HF + JK-1 10weeks post TAC. LVEDD, LVESD, and LVEF data were analyzed with 2-way-ANOVA, whereas LVEDP, Tau, and circulating BNP data were analyzed with 1-way ANOVA. Circles inside bars denote sample size. LVEDD = left ventricular end-diastolic dimensions; LVEF = left ventricular ejection fraction; LVESD = left ventricular end-systolic dimensions; other abbreviations as in Figure 1.