Figure 2: LCZ696 Treatment Improves Survival and LV Dysfunction After MI

(A, B) Kaplan-Meier survival curves for overall and cardiac rupture-free survival for MI mice treated with vehicle, enalapril, and LCZ696. n ≥75 mice per group. ∗p < 0.01 for log-rank test, †p < 0.05 for log-rank test. (C) Number of mice of the vehicle (24 of 77), enalapril (21 of 79), and LCZ696 (10 of 75) groups that died with cardiac rupture within 1 week after MI. (D to F) Serial measurements of (D) fractional shortening, (E) LV end-diastolic dimension, and (F) LV end-systolic dimension in MI mice treated with vehicle, enalapril, and LCZ696. Results were mean ± SD. n ≥ 34 per group. ∗p < 0.01 LCZ696 versus vehicle at 14 days and 28 days after MI, Bonferroni’s multiple comparison test. LV = left ventricular; other abbreviation as in Figure 1.