Figure 2: Expression of Plaque-Associated Biomolecules in Unobstructed Coronary Arteries, Across Obstructive/Narrowed Lesions and After Angioplasty of Coronary Atherosclerotic Plaques

(A) A summary is shown of biomarker gradients measured in blood sampled across the proximal to distal ports of the LBS system. (B) In 1 study, samples were taken from unobstructed vessels (green vessel). (C) In a separate study, samples were taken from narrowed or obstructive atherosclerotic plaques, where possible, before balloon dilation (yellow vessel) and in the same and other vessels (D) (red vessel) after balloon dilation. Data are volcano plots, with each identified biomolecular gradient represented by a single point, with effect size (median percentage of change of biomolecule concentration over a distance of 6 cm [PP-DP] within coronary artery) plotted on the x-axis and statistical significance (−log10[p value]) on the y-axis. The dashed horizontal line on each graph represents corrected threshold for significance of each gradient (p[FDR] <0.05); the vertical dashed line represents zero gradient. p(FDR) = false discovery rate p value; NPX = normalized protein expression.