Figure 2: Effects on Force Production and Stiffness

Effects on force production and stiffness with [2% dATP/98% ATP] compared with 100% ATP (5 mmol/l total) in rat cardiac muscle. (A) Example force trace (pCa 5.6) showing increased force production with transfer from 100% ATP to [2% dATP/98% ATP] and reduction of force after transfer back to 100% ATP. (B) % increases in force production and stiffness of cardiac trabeculae with [2% dATP/98% ATP] at submaximal (pCa 5.6) and maximal (pCa 4.0) Ca2+ levels.